{"id":77,"date":"2024-09-21T19:47:48","date_gmt":"2024-09-21T19:47:48","guid":{"rendered":"https:\/\/new.pulse1study.com\/?page_id=77"},"modified":"2025-03-07T20:40:56","modified_gmt":"2025-03-07T20:40:56","slug":"heart-2","status":"publish","type":"page","link":"https:\/\/heart2study.com\/fr\/heart-2\/","title":{"rendered":"Coeur-2"},"content":{"rendered":"<section class=\"bde-section-77-102 bde-section\">\n  \n  \n\t\n\n\n\n<div class=\"section-container\"><div id=\"heart-2-hero-en\" class=\"bde-image-77-103 bde-image\">\n<figure class=\"breakdance-image breakdance-image--314\">\n\t<div class=\"breakdance-image-container\">\n\t\t<div class=\"breakdance-image-clip\"><img loading=\"lazy\" decoding=\"async\" class=\"breakdance-image-object\" src=\"https:\/\/heart2study.com\/wp-content\/uploads\/sites\/6\/2024\/11\/french_hero-heart-2.jpg\" width=\"1248\" height=\"614\" srcset=\"https:\/\/heart2study.com\/wp-content\/uploads\/sites\/6\/2024\/11\/french_hero-heart-2.jpg 1248w, https:\/\/heart2study.com\/wp-content\/uploads\/sites\/6\/2024\/11\/french_hero-heart-2-300x148.jpg 300w, https:\/\/heart2study.com\/wp-content\/uploads\/sites\/6\/2024\/11\/french_hero-heart-2-1024x504.jpg 1024w, https:\/\/heart2study.com\/wp-content\/uploads\/sites\/6\/2024\/11\/french_hero-heart-2-768x378.jpg 768w, https:\/\/heart2study.com\/wp-content\/uploads\/sites\/6\/2024\/11\/french_hero-heart-2-18x9.jpg 18w\" sizes=\"auto, (max-width: 1248px) 100vw, 1248px\" alt=\"Heart-2 hero image of man playing with a dog\"><\/div>\n\t<\/div><\/figure>\n\n<\/div><div id=\"heart-2-hero-fr\" class=\"bde-image-77-283 bde-image\">\n<figure class=\"breakdance-image breakdance-image--352\">\n\t<div class=\"breakdance-image-container\">\n\t\t<div class=\"breakdance-image-clip\"><img loading=\"lazy\" decoding=\"async\" class=\"breakdance-image-object\" src=\"https:\/\/heart2study.com\/wp-content\/uploads\/2024\/09\/heart-2-hero_fr-1.jpg\" width=\"1248\" height=\"614\" srcset=\"https:\/\/heart2study.com\/wp-content\/uploads\/2024\/09\/heart-2-hero_fr-1.jpg 1248w, https:\/\/heart2study.com\/wp-content\/uploads\/2024\/09\/heart-2-hero_fr-1-300x148.jpg 300w, https:\/\/heart2study.com\/wp-content\/uploads\/2024\/09\/heart-2-hero_fr-1-1024x504.jpg 1024w, https:\/\/heart2study.com\/wp-content\/uploads\/2024\/09\/heart-2-hero_fr-1-768x378.jpg 768w\" sizes=\"auto, (max-width: 1248px) 100vw, 1248px\" alt=\"Heart-2 hero image of man playing with a dog\"><\/div>\n\t<\/div><\/figure>\n\n<\/div><div class=\"bde-div-77-278 bde-div\">\n  \n  \n\t\n\n\n\n<div class=\"bde-div-77-281 bde-div\">\n  \n  \n\t\n\n\n\n<h3 class=\"bde-heading-77-282 bde-heading\">\nOne Dose : Pourrait-elle aider \u00e0 vaincre l\u2019hypercholest\u00e9rol\u00e9mie?\n<\/h3>\n<\/div><div class=\"bde-text-77-280 bde-text\">\nVous pourrez peut-\u00eatre participer \u00e0 l'\u00e9tude Heart-2.\n<\/div>\n<\/div><div class=\"bde-button-77-104 bde-button\">\n        \n    \n    \n    \n    \n            \n                    \n            \n            \n\n    \n    \n    \n    \n    \n    <a class=\"breakdance-link button-atom button-atom--primary bde-button__button\" href=\"\/\" target=\"_self\" data-type=\"url\"  >\n\n    \n        <span class=\"button-atom__text\">Accueil des \u00e9tudes<\/span>\n\n        \n        \n                <\/a>\n\n    \n\n\n<\/div><div class=\"bde-text-77-105 bde-text\">\nL\u2019\u00e9tude Heart-2 aidera \u00e0 d\u00e9terminer si une dose unique d\u2019un m\u00e9dicament exp\u00e9rimental, appel\u00e9 VERVE-102, peut r\u00e9duire de mani\u00e8re s\u00e9curitaire et permanente le cholest\u00e9rol des lipoprot\u00e9ines de basse densit\u00e9 (LDL-C) ou le \u00ab mauvais \u00bb cholest\u00e9rol chez les personnes atteintes d\u2019hypercholest\u00e9rol\u00e9mie familiale h\u00e9t\u00e9rozygote (HeFH) et\/ou de maladie coronarienne pr\u00e9matur\u00e9e (MCP).\n<\/div><div class=\"bde-image-77-106 bde-image\">\n<figure class=\"breakdance-image breakdance-image--528\">\n\t<div class=\"breakdance-image-container\">\n\t\t<div class=\"breakdance-image-clip\"><img loading=\"lazy\" decoding=\"async\" class=\"breakdance-image-object\" src=\"https:\/\/heart2study.com\/wp-content\/uploads\/2024\/10\/Heart-2-Shield-NEW.png\" width=\"85\" height=\"102\" sizes=\"auto, (max-width: 85px) 100vw, 85px\" alt=\"purple shield\"><\/div>\n\t<\/div><\/figure>\n\n<\/div><div class=\"bde-code-block-77-277 bde-code-block\">\n\n\n\n<\/div><\/div>\n<\/section><section class=\"bde-section-77-107 bde-section\">\n  \n  \n\t\n\n\n\n<div class=\"section-container\"><div class=\"bde-div-77-108 bde-div\">\n              \n  \n  \n\t\n\n\n\n<div class=\"bde-menu-77-109 bde-menu\">\n\n\n      \n        \n    <nav class=\"breakdance-menu breakdance-menu--collapse\">\n    <button class=\"breakdance-menu-toggle breakdance-menu-toggle--squeeze\" type=\"button\" aria-label=\"Ouvrir le menu\" aria-expanded=\"false\" aria-controls=\"menu-109\">\n                  <span class=\"breakdance-menu-toggle-icon\">\n            <span class=\"breakdance-menu-toggle-lines\"><\/span>\n          <\/span>\n            <\/button>\n    \n  <ul class=\"breakdance-menu-list\" id=\"menu-109\">\n              \n  \n    <li class=\"bde-button-77-110 bde-button breakdance-menu-item\">\n        \n    \n    \n    \n    \n            \n                    \n            \n            \n\n    \n    \n    \n    \n    \n    <a class=\"breakdance-link button-atom button-atom--custom bde-button__button\" href=\"#about\" target=\"_self\" data-type=\"url\"  >\n\n    \n        <span class=\"button-atom__text\">\u00c0 propos de l\u2019\u00e9tude Heart-2<\/span>\n\n        \n        \n                <\/a>\n\n    \n\n\n<\/li><li class=\"bde-button-77-111 bde-button breakdance-menu-item\">\n        \n    \n    \n    \n    \n            \n                    \n            \n            \n\n    \n    \n    \n    \n    \n    <a class=\"breakdance-link button-atom button-atom--custom bde-button__button\" href=\"#what-to-expect\" target=\"_self\" data-type=\"url\"  >\n\n    \n        <span class=\"button-atom__text\">\u00c0 quoi s'attendre en participant \u00e0 l'\u00e9tude Heart-2<\/span>\n\n        \n        \n                <\/a>\n\n    \n\n\n<\/li><li class=\"bde-button-77-112 bde-button breakdance-menu-item\">\n        \n    \n    \n    \n    \n            \n                    \n            \n            \n\n    \n    \n    \n    \n    \n    <a class=\"breakdance-link button-atom button-atom--custom bde-button__button\" href=\"#participant-qualifications\" target=\"_self\" data-type=\"url\"  >\n\n    \n        <span class=\"button-atom__text\">Qualifications des participants<\/span>\n\n        \n        \n                <\/a>\n\n    \n\n\n<\/li><li class=\"bde-button-77-113 bde-button breakdance-menu-item\">\n        \n    \n    \n    \n    \n            \n                    \n            \n            \n\n    \n    \n    \n    \n    \n    <a class=\"breakdance-link button-atom button-atom--custom bde-button__button\" href=\"#qualify\" target=\"_self\" data-type=\"url\"  >\n\n    \n        <span class=\"button-atom__text\">V\u00e9rifiez si vous \u00eates pr\u00e9qualifi\u00e9<\/span>\n\n        \n        \n                <\/a>\n\n    \n\n\n<\/li><li class=\"bde-button-77-114 bde-button breakdance-menu-item\">\n        \n    \n    \n    \n    \n            \n                    \n            \n            \n\n    \n    \n    \n    \n    \n    <a class=\"breakdance-link button-atom button-atom--custom bde-button__button\" href=\"#details\" target=\"_self\" data-type=\"url\"  >\n\n    \n        <span class=\"button-atom__text\">P\u00e9riodes d'\u00e9tudes<\/span>\n\n        \n        \n                <\/a>\n\n    \n\n\n<\/li><li class=\"bde-button-77-115 bde-button breakdance-menu-item\">\n        \n    \n    \n    \n    \n            \n                    \n            \n            \n\n    \n    \n    \n    \n    \n    <a class=\"breakdance-link button-atom button-atom--custom bde-button__button\" href=\"#locations\" target=\"_self\" data-type=\"url\"  >\n\n    \n        <span class=\"button-atom__text\">Lieux d\u2019\u00e9tude<\/span>\n\n        \n        \n                <\/a>\n\n    \n\n\n<\/li>\n  <\/ul>\n  <\/nav>\n\n\n<\/div>\n<\/div><\/div>\n<\/section><section id=\"about\" class=\"bde-section-77-116 bde-section\">\n  \n  \n\t\n\n\n\n<div class=\"section-container\"><div class=\"bde-columns-77-117 bde-columns\"><div class=\"bde-column-77-118 bde-column\">\n  \n  \n\t\n\n\n\n<h2 class=\"bde-heading-77-121 bde-heading\">\n\u00c0 propos de l'\u00e9tude Heart-2\n<\/h2><div class=\"bde-rich-text-77-123 bde-rich-text breakdance-rich-text-styles\">\n<p>L\u2019\u00e9tude Heart-2 est un essai clinique destin\u00e9 aux personnes atteintes d\u2019hypercholest\u00e9rol\u00e9mie familiale h\u00e9t\u00e9rozygote (HFH) et\/ou de coronaropathie pr\u00e9matur\u00e9e (CAP) et de taux \u00e9lev\u00e9s de cholest\u00e9rol \u00e0 lipoprot\u00e9ines de basse densit\u00e9 (LDL-C). L\u2019objectif de l\u2019\u00e9tude Heart-2 est d\u2019\u00e9valuer l\u2019innocuit\u00e9 et la tol\u00e9rance de VERVE-102 et de voir s\u2019il peut aider \u00e0 r\u00e9duire les taux de LDL-C avec une dose unique.<br \/>\u00a0<br \/>VERVE-102 est con\u00e7u pour arr\u00eater de fa\u00e7on permanente la production de la prot\u00e9ine PCSK9 dans le foie en inactivant l'enzyme de la prot\u00e9ine PCSK9. <em>PCSK9<\/em> VERVE-102 est con\u00e7u pour arr\u00eater d\u00e9finitivement la production de la prot\u00e9ine PCSK9 dans le foie en inactivant le g\u00e8ne PCSK9 \u00e0 l\u2019aide d\u2019une approche appel\u00e9e \u00e9dition g\u00e9n\u00e9tique. Cela peut r\u00e9duire les taux de LDL-C dans la circulation sanguine. Comme l\u2019\u00e9dition g\u00e9n\u00e9tique est cens\u00e9e \u00eatre un changement permanent, elle n\u2019est administr\u00e9e qu\u2019une seule fois par perfusion intraveineuse (IV), ce qui signifie qu\u2019elle sera administr\u00e9e dans une veine.<\/p>\n<\/div>\n<\/div><div class=\"bde-column-77-119 bde-column\">\n  \n  \n\t\n\n\n\n<div class=\"bde-image-77-120 bde-image\">\n<figure class=\"breakdance-image breakdance-image--276\">\n\t<div class=\"breakdance-image-container\">\n\t\t<div class=\"breakdance-image-clip\"><img loading=\"lazy\" decoding=\"async\" class=\"breakdance-image-object\" src=\"https:\/\/heart2study.com\/wp-content\/uploads\/2024\/09\/2-2.png\" width=\"528\" height=\"404\" srcset=\"https:\/\/heart2study.com\/wp-content\/uploads\/2024\/09\/2-2.png 528w, https:\/\/heart2study.com\/wp-content\/uploads\/2024\/09\/2-2-300x230.png 300w\" sizes=\"auto, (max-width: 528px) 100vw, 528px\" alt=\"Nurse giving patient a shot\"><\/div>\n\t<\/div><\/figure>\n\n<\/div>\n<\/div><\/div><div class=\"bde-div-77-290 bde-div\">\n  \n  \n\t\n\n\n\n<h3 class=\"bde-heading-77-124 bde-heading\">\nA propos du m\u00e9dicament exp\u00e9rimental\n<\/h3><div class=\"bde-text-77-125 bde-text\">\nLe m\u00e9dicament exp\u00e9rimental VERVE-102 cible un g\u00e8ne connu pour provoquer des taux \u00e9lev\u00e9s de cholest\u00e9rol \u00e0 lipoprot\u00e9ines de basse densit\u00e9 (LDL-C) dans le sang. Des taux \u00e9lev\u00e9s de LDL-C contribuent \u00e0 des \u00e9v\u00e9nements cardiovasculaires graves, tels que des crises cardiaques et des accidents vasculaires c\u00e9r\u00e9braux. L'\u00e9tude Heart-2 pourrait permettre de d\u00e9couvrir une avanc\u00e9e potentielle dans le traitement des taux \u00e9lev\u00e9s de LDL-C.\n<\/div><div id=\"brochure-en\" class=\"bde-button-77-284 bde-button\">\n        \n    \n    \n    \n    \n            \n                    \n            \n            \n\n    \n    \n    \n    \n    \n    <a class=\"breakdance-link button-atom button-atom--custom bde-button__button\" href=\"https:\/\/heart2study.com\/wp-content\/uploads\/sites\/6\/2024\/11\/Heart-2_PatientBrochure_Digital_19Sep024_V2.0_CA_FR.pdf\" target=\"_self\" data-type=\"url\"  >\n\n    \n        <span class=\"button-atom__text\">T\u00e9l\u00e9charger la brochure<\/span>\n\n                            \n        \n                <\/a>\n\n    \n\n\n<\/div>\n<\/div><\/div>\n<\/section><section class=\"bde-section-77-126 bde-section\">\n              \n  \n  \n\t\n\n\n\n<div class=\"section-container\"><h4 class=\"bde-heading-77-127 bde-heading\">\nHypercholest\u00e9rol\u00e9mie familiale h\u00e9t\u00e9rozygote (HFHe) et <br>maladie coronarienne pr\u00e9matur\u00e9e (MCP)\n<\/h4><div class=\"bde-text-77-128 bde-text\">\nBien que les taux \u00e9lev\u00e9s de cholest\u00e9rol \u00e0 lipoprot\u00e9ines de basse densit\u00e9 (LDL-C) soient nocifs pour tout le monde, ils sont particuli\u00e8rement graves et plus difficiles \u00e0 g\u00e9rer pour certains groupes de personnes. Voici deux exemples :\n<\/div><div class=\"bde-columns-77-130 bde-columns\"><div class=\"bde-column-77-131 bde-column\">\n  \n  \n\t\n\n\n\n<h5 class=\"bde-heading-77-133 bde-heading\">\nIlFH\n<\/h5><div class=\"bde-text-77-134 bde-text\">\nL'HF est une maladie qui entra\u00eene des taux \u00e9lev\u00e9s de LDL-C tout au long de la vie en raison de la g\u00e9n\u00e9tique de la personne. Cela signifie que la personne a h\u00e9rit\u00e9 de la maladie. Il existe souvent des ant\u00e9c\u00e9dents familiaux de taux \u00e9lev\u00e9s de LDL-C ou d'\u00e9v\u00e9nements cardiovasculaires (CV) tels que des crises cardiaques ou des accidents vasculaires c\u00e9r\u00e9braux (AVC) au d\u00e9but de la vie.\n<\/div>\n<\/div><div class=\"bde-column-77-132 bde-column\">\n  \n  \n\t\n\n\n\n<h5 class=\"bde-heading-77-135 bde-heading\">\nCAD pr\u00e9matur\u00e9\n<\/h5><div class=\"bde-text-77-136 bde-text\">\nLa maladie coronarienne, ou MC, r\u00e9sulte de la formation de d\u00e9p\u00f4ts graisseux dans les art\u00e8res qui alimentent le c\u0153ur en sang et en nutriments, appel\u00e9es art\u00e8res coronaires. La MC se d\u00e9veloppe g\u00e9n\u00e9ralement plus tard dans la vie. On parle de MC pr\u00e9matur\u00e9e chez les personnes qui ont d\u00e9velopp\u00e9 une maladie cardiaque grave due \u00e0 un taux de cholest\u00e9rol \u00e9lev\u00e9 avant l'\u00e2ge de 65 ans chez les femmes ou avant l'\u00e2ge de 55 ans chez les hommes. La prise en charge de la MC implique g\u00e9n\u00e9ralement des efforts tout au long de la vie pour r\u00e9duire le taux de LDL-C.\n<\/div>\n<\/div><\/div><\/div>\n<\/section><section id=\"what-to-expect\" class=\"bde-section-77-137 bde-section\">\n  \n  \n\t\n\n\n\n<div class=\"section-container\"><h3 class=\"bde-heading-77-138 bde-heading\">\n\u00c0 quoi s'attendre en participant \u00e0 l'\u00e9tude Heart-2 ?\n<\/h3><div class=\"bde-grid-77-139 bde-grid\">\n  \n  \n\t\n\n\n\n<div class=\"bde-div-77-140 bde-div\">\n  \n  \n\t\n\n\n\n<div class=\"bde-image-77-141 bde-image\">\n<figure class=\"breakdance-image breakdance-image--48\">\n\t<div class=\"breakdance-image-container\">\n\t\t<div class=\"breakdance-image-clip\"><img loading=\"lazy\" decoding=\"async\" class=\"breakdance-image-object\" src=\"https:\/\/heart2study.com\/wp-content\/uploads\/2024\/09\/warning-icon.jpg\" width=\"165\" height=\"164\" srcset=\"https:\/\/heart2study.com\/wp-content\/uploads\/2024\/09\/warning-icon.jpg 165w, https:\/\/heart2study.com\/wp-content\/uploads\/2024\/09\/warning-icon-150x150.jpg 150w\" sizes=\"auto, (max-width: 165px) 100vw, 165px\" alt=\"Warning Icon\"><\/div>\n\t<\/div><\/figure>\n\n<\/div><div class=\"bde-text-77-142 bde-text\">\nL'\u00e9quipe de l'essai clinique expliquera les avantages et les risques possibles de la participation.\n<\/div>\n<\/div><div class=\"bde-div-77-143 bde-div\">\n  \n  \n\t\n\n\n\n<div class=\"bde-image-77-144 bde-image\">\n<figure class=\"breakdance-image breakdance-image--372\">\n\t<div class=\"breakdance-image-container\">\n\t\t<div class=\"breakdance-image-clip\"><img loading=\"lazy\" decoding=\"async\" class=\"breakdance-image-object\" src=\"https:\/\/heart2study.com\/wp-content\/uploads\/2024\/09\/icon1NEW.png\" width=\"165\" height=\"164\" srcset=\"https:\/\/heart2study.com\/wp-content\/uploads\/2024\/09\/icon1NEW.png 165w, https:\/\/heart2study.com\/wp-content\/uploads\/2024\/09\/icon1NEW-150x150.png 150w\" sizes=\"auto, (max-width: 165px) 100vw, 165px\"><\/div>\n\t<\/div><\/figure>\n\n<\/div><div class=\"bde-text-77-145 bde-text\">\nSi vous choisissez de participer \u00e0 un essai clinique, vous pouvez arr\u00eater de participer \u00e0 tout moment.\n<\/div>\n<\/div><div class=\"bde-div-77-146 bde-div\">\n  \n  \n\t\n\n\n\n<div class=\"bde-image-77-147 bde-image\">\n<figure class=\"breakdance-image breakdance-image--46\">\n\t<div class=\"breakdance-image-container\">\n\t\t<div class=\"breakdance-image-clip\"><img loading=\"lazy\" decoding=\"async\" class=\"breakdance-image-object\" src=\"https:\/\/heart2study.com\/wp-content\/uploads\/2024\/09\/money-icon.jpg\" width=\"165\" height=\"164\" srcset=\"https:\/\/heart2study.com\/wp-content\/uploads\/2024\/09\/money-icon.jpg 165w, https:\/\/heart2study.com\/wp-content\/uploads\/2024\/09\/money-icon-150x150.jpg 150w\" sizes=\"auto, (max-width: 165px) 100vw, 165px\" alt=\"Money Icon\"><\/div>\n\t<\/div><\/figure>\n\n<\/div><div class=\"bde-text-77-148 bde-text\">\nVous serez rembours\u00e9 pour votre temps de participation.\n<\/div>\n<\/div><div class=\"bde-div-77-149 bde-div\">\n  \n  \n\t\n\n\n\n<div class=\"bde-image-77-150 bde-image\">\n<figure class=\"breakdance-image breakdance-image--45\">\n\t<div class=\"breakdance-image-container\">\n\t\t<div class=\"breakdance-image-clip\"><img loading=\"lazy\" decoding=\"async\" class=\"breakdance-image-object\" src=\"https:\/\/heart2study.com\/wp-content\/uploads\/2024\/09\/plane-icon.jpg\" width=\"165\" height=\"164\" srcset=\"https:\/\/heart2study.com\/wp-content\/uploads\/2024\/09\/plane-icon.jpg 165w, https:\/\/heart2study.com\/wp-content\/uploads\/2024\/09\/plane-icon-150x150.jpg 150w\" sizes=\"auto, (max-width: 165px) 100vw, 165px\" alt=\"Plane icon\"><\/div>\n\t<\/div><\/figure>\n\n<\/div><div class=\"bde-text-77-151 bde-text\">\nVous serez rembours\u00e9 pour les frais de d\u00e9placement et autres d\u00e9penses pendant votre participation.\n<\/div>\n<\/div><div class=\"bde-div-77-152 bde-div\">\n  \n  \n\t\n\n\n\n<div class=\"bde-image-77-153 bde-image\">\n<figure class=\"breakdance-image breakdance-image--44\">\n\t<div class=\"breakdance-image-container\">\n\t\t<div class=\"breakdance-image-clip\"><img loading=\"lazy\" decoding=\"async\" class=\"breakdance-image-object\" src=\"https:\/\/heart2study.com\/wp-content\/uploads\/2024\/09\/medicine-icon.jpg\" width=\"164\" height=\"164\" srcset=\"https:\/\/heart2study.com\/wp-content\/uploads\/2024\/09\/medicine-icon.jpg 164w, https:\/\/heart2study.com\/wp-content\/uploads\/2024\/09\/medicine-icon-150x150.jpg 150w\" sizes=\"auto, (max-width: 164px) 100vw, 164px\" alt=\"Medicine icon\"><\/div>\n\t<\/div><\/figure>\n\n<\/div><div class=\"bde-text-77-154 bde-text\">\nLes m\u00e9dicaments d'essai clinique et les tests li\u00e9s aux essais cliniques seront gratuits pour les participants.\n<\/div>\n<\/div><div class=\"bde-div-77-155 bde-div\">\n  \n  \n\t\n\n\n\n<div class=\"bde-image-77-156 bde-image\">\n<figure class=\"breakdance-image breakdance-image--43\">\n\t<div class=\"breakdance-image-container\">\n\t\t<div class=\"breakdance-image-clip\"><img loading=\"lazy\" decoding=\"async\" class=\"breakdance-image-object\" src=\"https:\/\/heart2study.com\/wp-content\/uploads\/2024\/09\/healthcare-icon.jpg\" width=\"164\" height=\"164\" srcset=\"https:\/\/heart2study.com\/wp-content\/uploads\/2024\/09\/healthcare-icon.jpg 164w, https:\/\/heart2study.com\/wp-content\/uploads\/2024\/09\/healthcare-icon-150x150.jpg 150w\" sizes=\"auto, (max-width: 164px) 100vw, 164px\" alt=\"Doctors icon\"><\/div>\n\t<\/div><\/figure>\n\n<\/div><div class=\"bde-text-77-157 bde-text\">\nUne \u00e9quipe de m\u00e9decins et d'infirmi\u00e8res surveillera attentivement votre sant\u00e9 pendant l'essai clinique.\n<\/div>\n<\/div><div class=\"bde-div-77-158 bde-div\">\n  \n  \n\t\n\n\n\n<div class=\"bde-image-77-159 bde-image\">\n<figure class=\"breakdance-image breakdance-image--42\">\n\t<div class=\"breakdance-image-container\">\n\t\t<div class=\"breakdance-image-clip\"><img loading=\"lazy\" decoding=\"async\" class=\"breakdance-image-object\" src=\"https:\/\/heart2study.com\/wp-content\/uploads\/2024\/09\/documents-icon.jpg\" width=\"164\" height=\"164\" srcset=\"https:\/\/heart2study.com\/wp-content\/uploads\/2024\/09\/documents-icon.jpg 164w, https:\/\/heart2study.com\/wp-content\/uploads\/2024\/09\/documents-icon-150x150.jpg 150w\" sizes=\"auto, (max-width: 164px) 100vw, 164px\"><\/div>\n\t<\/div><\/figure>\n\n<\/div><div class=\"bde-text-77-160 bde-text\">\nL'essai clinique a \u00e9t\u00e9 approuv\u00e9 par un comit\u00e9 d'\u00e9thique\/d'examen institutionnel et par l'autorit\u00e9 sanitaire nationale, ce qui prot\u00e8ge les droits, la s\u00e9curit\u00e9 et le bien-\u00eatre des participants.\n<\/div>\n<\/div>\n<\/div><\/div>\n<\/section><section class=\"bde-section-77-161 bde-section\">\n  \n  \n\t\n\n\n\n<div class=\"section-container\"><\/div>\n<\/section><section id=\"participant-qualifications\" class=\"bde-section-77-163 bde-section\">\n  \n  \n\t\n\n\n\n<div class=\"section-container\"><div class=\"bde-columns-77-164 bde-columns\"><div class=\"bde-column-77-165 bde-column\">\n  \n  \n\t\n\n\n\n<div class=\"bde-image-77-167 bde-image\">\n<figure class=\"breakdance-image breakdance-image--88\">\n\t<div class=\"breakdance-image-container\">\n\t\t<div class=\"breakdance-image-clip\"><img loading=\"lazy\" decoding=\"async\" class=\"breakdance-image-object\" src=\"https:\/\/heart2study.com\/wp-content\/uploads\/2024\/09\/Participant-qualifications.png\" width=\"555\" height=\"686\" srcset=\"https:\/\/heart2study.com\/wp-content\/uploads\/2024\/09\/Participant-qualifications.png 555w, https:\/\/heart2study.com\/wp-content\/uploads\/2024\/09\/Participant-qualifications-243x300.png 243w\" sizes=\"auto, (max-width: 555px) 100vw, 555px\" alt=\"Man and Woman smiling\"><\/div>\n\t<\/div><\/figure>\n\n<\/div>\n<\/div><div class=\"bde-column-77-166 bde-column\">\n  \n  \n\t\n\n\n\n<h2 class=\"bde-heading-77-168 bde-heading\">\nQualifications des participants\n<\/h2><div class=\"bde-text-77-169 bde-text\">\nVous pouvez participer si vous* :\n<\/div><div class=\"bde-columns-77-171 bde-columns\"><div class=\"bde-column-77-172 bde-column\">\n  \n  \n\t\n\n\n\n<div class=\"bde-image-77-174 bde-image\">\n<figure class=\"breakdance-image breakdance-image--89\">\n\t<div class=\"breakdance-image-container\">\n\t\t<div class=\"breakdance-image-clip\"><img loading=\"lazy\" decoding=\"async\" class=\"breakdance-image-object\" src=\"https:\/\/heart2study.com\/wp-content\/uploads\/2024\/09\/paople-hands-icon.png\" width=\"53\" height=\"45\" sizes=\"auto, (max-width: 53px) 100vw, 53px\" alt=\"People in hands icon\"><\/div>\n\t<\/div><\/figure>\n\n<\/div>\n<\/div><div class=\"bde-column-77-173 bde-column\">\n  \n  \n\t\n\n\n\n<div class=\"bde-text-77-177 bde-text\">\nOnt entre 18 et 70 ans\n<\/div><div class=\"bde-text-77-176 bde-text\">\n(les participantes ne peuvent pas \u00eatre enceintes ou susceptibles de <br>devenir enceintes)\n<\/div>\n<\/div><\/div><div class=\"bde-columns-77-190 bde-columns\"><div class=\"bde-column-77-191 bde-column\">\n  \n  \n\t\n\n\n\n<div class=\"bde-image-77-192 bde-image\">\n<figure class=\"breakdance-image breakdance-image--90\">\n\t<div class=\"breakdance-image-container\">\n\t\t<div class=\"breakdance-image-clip\"><img loading=\"lazy\" decoding=\"async\" class=\"breakdance-image-object\" src=\"https:\/\/heart2study.com\/wp-content\/uploads\/2024\/09\/heart-icon.png\" width=\"50\" height=\"46\" sizes=\"auto, (max-width: 50px) 100vw, 50px\" alt=\"Heart icon\"><\/div>\n\t<\/div><\/figure>\n\n<\/div>\n<\/div><div class=\"bde-column-77-193 bde-column\">\n  \n  \n\t\n\n\n\n<div class=\"bde-text-77-194 bde-text\">\nAvoir un diagnostic d'HFHe et\/ou de coronaropathie pr\u00e9matur\u00e9e\n<\/div>\n<\/div><\/div><div class=\"bde-columns-77-184 bde-columns\"><div class=\"bde-column-77-185 bde-column\">\n  \n  \n\t\n\n\n\n<div class=\"bde-image-77-186 bde-image\">\n<figure class=\"breakdance-image breakdance-image--91\">\n\t<div class=\"breakdance-image-container\">\n\t\t<div class=\"breakdance-image-clip\"><img loading=\"lazy\" decoding=\"async\" class=\"breakdance-image-object\" src=\"https:\/\/heart2study.com\/wp-content\/uploads\/2024\/09\/up-blood-icon.png\" width=\"48\" height=\"52\" sizes=\"auto, (max-width: 48px) 100vw, 48px\" alt=\"Blood icon\"><\/div>\n\t<\/div><\/figure>\n\n<\/div>\n<\/div><div class=\"bde-column-77-187 bde-column\">\n  \n  \n\t\n\n\n\n<div class=\"bde-text-77-188 bde-text\">\nAvoir des taux \u00e9lev\u00e9s de LDL-C m\u00eame si vous \u00eates trait\u00e9 avec des statines ou des m\u00e9dicaments hypocholest\u00e9rol\u00e9miants\n<\/div>\n<\/div><\/div><div class=\"bde-columns-77-178 bde-columns\"><div class=\"bde-column-77-179 bde-column\">\n  \n  \n\t\n\n\n\n<div class=\"bde-image-77-180 bde-image\">\n<figure class=\"breakdance-image breakdance-image--92\">\n\t<div class=\"breakdance-image-container\">\n\t\t<div class=\"breakdance-image-clip\"><img loading=\"lazy\" decoding=\"async\" class=\"breakdance-image-object\" src=\"https:\/\/heart2study.com\/wp-content\/uploads\/2024\/09\/medicine-icon.png\" width=\"43\" height=\"53\" sizes=\"auto, (max-width: 43px) 100vw, 43px\" alt=\"Medicine icon\"><\/div>\n\t<\/div><\/figure>\n\n<\/div>\n<\/div><div class=\"bde-column-77-181 bde-column\">\n  \n  \n\t\n\n\n\n<div class=\"bde-text-77-182 bde-text\">\nVous ne prenez pas d\u2019inhibiteur de PCSK9 tel que Praluent<sup>MD<\/sup> (alirocumab), Repatha<sup>MD<\/sup> (evolocumab) ou Leqvio<sup>MD<\/sup> (inclisiran).\n<\/div>\n<\/div><\/div><div class=\"bde-text-77-202 bde-text\">\n*Des crit\u00e8res d'admissibilit\u00e9 suppl\u00e9mentaires s'appliquent\n<\/div><div class=\"bde-button-77-196 bde-button\">\n        \n    \n    \n    \n    \n            \n                    \n            \n            \n\n    \n    \n    \n    \n    \n    <a class=\"breakdance-link button-atom button-atom--secondary bde-button__button\" href=\"#qualify\" target=\"_self\" data-type=\"url\"  >\n\n    \n        <span class=\"button-atom__text\">V\u00e9rifiez si vous \u00eates pr\u00e9qualifi\u00e9<\/span>\n\n        \n        \n                <\/a>\n\n    \n\n\n<\/div><div class=\"bde-button-77-319 bde-button\">\n        \n    \n    \n    \n    \n            \n                    \n            \n            \n\n    \n    \n    \n    \n    \n    <a class=\"breakdance-link button-atom button-atom--secondary bde-button__button\" href=\"#qualify-mobile\" target=\"_self\" data-type=\"url\"  >\n\n    \n        <span class=\"button-atom__text\">V\u00e9rifiez si vous \u00eates pr\u00e9qualifi\u00e9<\/span>\n\n        \n        \n                <\/a>\n\n    \n\n\n<\/div>\n<\/div><\/div><\/div>\n<\/section><section id=\"qualify\" class=\"bde-section-77-291 bde-section\">\n  \n  \n\t\n\n\n\n<div class=\"section-container\"><div class=\"bde-div-77-307 bde-div\">\n  \n  \n\t\n\n\n\n<div class=\"bde-columns-77-308 bde-columns\"><div class=\"bde-column-77-309 bde-column\">\n  \n  \n\t\n\n\n\n\n<\/div><div class=\"bde-column-77-310 bde-column\">\n  \n  \n\t\n\n\n\n<h3 class=\"bde-heading-77-298 bde-heading\">\nV\u00e9rifiez si vous \u00eates pr\u00e9qualifi\u00e9\n<\/h3><div class=\"bde-text-77-299 bde-text\">\nR\u00e9pondez \u00e0 quelques questions pour savoir si vous pouvez participer \u00e0 un essai clinique.\n<\/div><div class=\"bde-rich-text-77-321 bde-rich-text breakdance-rich-text-styles\">\n<p>Vos informations sont stock\u00e9es dans une base de donn\u00e9es conforme \u00e0 la loi HIPAA et fournies aux sites d'essai pour le suivi, le cas \u00e9ch\u00e9ant. Pour plus d'informations, veuillez consulter notre page sur la politique de protection de la vie priv\u00e9e. <a href=\"\/privacy-policy\/\">veuillez consulter notre page sur la politique de protection de la vie priv\u00e9e<\/a>.<\/p>\n<\/div>\n<\/div><\/div>\n<\/div><\/div>\n<\/section><section id=\"qualify-mobile\" class=\"bde-section-77-311 bde-section\">\n              \n  \n  \n\t\n\n\n\n<div class=\"section-container\"><div class=\"bde-div-77-312 bde-div\">\n  \n  \n\t\n\n\n\n<h3 class=\"bde-heading-77-313 bde-heading\">\nV\u00e9rifiez si vous \u00eates pr\u00e9qualifi\u00e9\n<\/h3><div class=\"bde-text-77-314 bde-text\">\nR\u00e9pondez \u00e0 quelques questions pour savoir si vous pouvez participer \u00e0 un essai clinique.\n<\/div><div class=\"bde-rich-text-77-316 bde-rich-text breakdance-rich-text-styles\">\n<p>Vos informations sont stock\u00e9es dans une base de donn\u00e9es conforme \u00e0 la loi HIPAA et fournies aux sites d'essai pour le suivi, le cas \u00e9ch\u00e9ant. Pour plus d'informations, veuillez consulter notre page sur la politique de protection de la vie priv\u00e9e. <a href=\"\/privacy-policy\/\">veuillez consulter notre page sur la politique de protection de la vie priv\u00e9e<\/a>.<\/p>\n<\/div>\n<\/div><\/div>\n<\/section><section id=\"qualify\" class=\"bde-section-77-317 bde-section\">\n  \n  \n\t\n\n\n\n<div class=\"section-container\"><div class=\"bde-image-77-318 bde-image\">\n<figure class=\"breakdance-image breakdance-image--744\">\n\t<div class=\"breakdance-image-container\">\n\t\t<div class=\"breakdance-image-clip\"><img loading=\"lazy\" decoding=\"async\" class=\"breakdance-image-object\" src=\"https:\/\/heart2study.com\/wp-content\/uploads\/2024\/10\/screener-heart2-mobile.jpg\" width=\"320\" height=\"420\" srcset=\"https:\/\/heart2study.com\/wp-content\/uploads\/2024\/10\/screener-heart2-mobile.jpg 320w, https:\/\/heart2study.com\/wp-content\/uploads\/2024\/10\/screener-heart2-mobile-229x300.jpg 229w\" sizes=\"auto, (max-width: 320px) 100vw, 320px\" alt=\"Hug\"><\/div>\n\t<\/div><\/figure>\n\n<\/div><\/div>\n<\/section><section id=\"details\" class=\"bde-section-77-212 bde-section\">\n  \n  \n\t\n\n\n\n<div class=\"section-container\"><div class=\"bde-div-77-213 bde-div\">\n  \n  \n\t\n\n\n\n<h2 class=\"bde-heading-77-214 bde-heading\">\nP\u00e9riodes d'\u00e9tudes\n<\/h2><div class=\"bde-columns-77-243 bde-columns\"><div class=\"bde-column-77-244 bde-column\">\n  \n  \n\t\n\n\n\n<div class=\"bde-text-77-246 bde-text large-text\">\n1\n<\/div>\n<\/div><div class=\"bde-column-77-245 bde-column\">\n  \n  \n\t\n\n\n\n<h4 class=\"bde-heading-77-247 bde-heading\">\nP\u00e9riode de projection\n<\/h4><div class=\"bde-text-77-248 bde-text\">\n(jusqu'\u00e0 3 mois)\n<\/div><div class=\"bde-text-77-249 bde-text\">\nVous participerez \u00e0 des rendez-vous de s\u00e9lection pour d\u00e9terminer votre admissibilit\u00e9 \u00e0 l\u2019essai. Au cours de ces rendez-vous, plusieurs tests seront effectu\u00e9s, notamment des prises de sang et des examens physiques.\n<\/div><div class=\"bde-rich-text-77-250 bde-rich-text breakdance-rich-text-styles\">\n<ul>\n<li aria-level=\"1\">Vous visiterez le site de l'\u00e9tude deux fois ou plus pour d\u00e9terminer si l'\u00e9tude vous convient. Si vous \u00eates admissible, vous aurez la possibilit\u00e9 de participer \u00e0 l'\u00e9tude.<\/li>\n<li aria-level=\"1\">Les visites de d\u00e9pistage doivent avoir lieu dans un d\u00e9lai de trois mois.<\/li>\n<\/ul>\n<\/div>\n<\/div><\/div><div class=\"bde-fancy-divider-77-267 bde-fancy-divider\">\n\n\n<div class=\"bde-fancy-divider__wrapper\">\n  <div class=\"bde-fancy-divider__separator\">\n  \t  <\/div>\n<\/div>\n\n<\/div><div class=\"bde-columns-77-259 bde-columns\"><div class=\"bde-column-77-260 bde-column\">\n  \n  \n\t\n\n\n\n<div class=\"bde-text-77-261 bde-text large-text\">\n2\n<\/div>\n<\/div><div class=\"bde-column-77-262 bde-column\">\n  \n  \n\t\n\n\n\n<h4 class=\"bde-heading-77-263 bde-heading\">\nP\u00e9riode de traitement de l'\u00e9tude\n<\/h4><div class=\"bde-text-77-264 bde-text\">\n(environ quatre jours)\n<\/div><div class=\"bde-text-77-265 bde-text\">\nSi vous \u00eates admissible et d\u00e9cidez de participer, la p\u00e9riode de traitement de l'\u00e9tude impliquera un s\u00e9jour d'environ quatre jours\/trois nuits sur le site de l'\u00e9tude, au cours duquel :\n<\/div><div class=\"bde-rich-text-77-266 bde-rich-text breakdance-rich-text-styles\">\n<ul><li aria-level=\"1\">Vous recevrez une dose unique de VERVE-102 sous forme de perfusion intraveineuse dans votre bras.<\/li><li aria-level=\"1\">Pendant votre s\u00e9jour sur le site de l'\u00e9tude, l'\u00e9quipe de l'\u00e9tude surveillera votre sant\u00e9 et effectuera des \u00e9valuations similaires \u00e0 celles de la p\u00e9riode de d\u00e9pistage afin de v\u00e9rifier votre tol\u00e9rance au VERVE-102. Si n\u00e9cessaire, votre s\u00e9jour peut \u00eatre prolong\u00e9 pour une surveillance suppl\u00e9mentaire.<\/li><\/ul>\n<\/div>\n<\/div><\/div><div class=\"bde-fancy-divider-77-268 bde-fancy-divider\">\n\n\n<div class=\"bde-fancy-divider__wrapper\">\n  <div class=\"bde-fancy-divider__separator\">\n  \t  <\/div>\n<\/div>\n\n<\/div><div class=\"bde-columns-77-251 bde-columns\"><div class=\"bde-column-77-252 bde-column\">\n  \n  \n\t\n\n\n\n<div class=\"bde-text-77-253 bde-text large-text\">\n3\n<\/div>\n<\/div><div class=\"bde-column-77-254 bde-column\">\n  \n  \n\t\n\n\n\n<h4 class=\"bde-heading-77-255 bde-heading\">\nP\u00e9riode de suivi\n<\/h4><div class=\"bde-text-77-256 bde-text\">\n(environ un an)\n<\/div><div class=\"bde-rich-text-77-258 bde-rich-text breakdance-rich-text-styles\">\n<ul><li aria-level=\"1\">Il y aura jusqu'\u00e0 10 visites de suivi au cours de l'ann\u00e9e apr\u00e8s avoir re\u00e7u VERVE-102 pour continuer \u00e0 surveiller votre sant\u00e9, y compris la visite de fin d'\u00e9tude.<\/li><li aria-level=\"1\">Apr\u00e8s la visite de fin d'\u00e9tude, vous continuerez \u00e0 participer \u00e0 une \u00e9tude de suivi \u00e0 long terme pour surveiller votre s\u00e9curit\u00e9 et votre taux de cholest\u00e9rol. La plupart de ces visites peuvent \u00eatre effectu\u00e9es \u00e0 domicile.<\/li><\/ul>\n<\/div>\n<\/div><\/div>\n<\/div><\/div>\n<\/section><section id=\"locations\" class=\"bde-section-77-269 bde-section\">\n  \n  \n\t\n\n\n\n<div class=\"section-container\"><h2 class=\"bde-heading-77-270 bde-heading\">\nEmplacement des sites d'\u00e9tude\n<\/h2><div class=\"bde-shortcode-77-272 bde-shortcode\"><style>\r\n\t#wpsl-stores .wpsl-store-thumb {height:45px !important; width:45px !important;}\r\n\t#wpsl-stores, #wpsl-direction-details, #wpsl-gmap {height:500px !important;}\r\n\t#wpsl-gmap .wpsl-info-window {max-width:225px !important;}\r\n\t.wpsl-input label, #wpsl-radius label, #wpsl-category label {width:150px;}\r\n\t#wpsl-search-input  {width:179px;}\r\n<\/style>\r\n<div id=\"wpsl-wrap\">\r\n\t<div class=\"wpsl-search wpsl-clearfix\">\r\n\t\t<div id=\"wpsl-search-wrap\">\r\n\t\t\t<form autocomplete=\"off\" action=\"\">\r\n\t\t\t<div class=\"wpsl-input\">\r\n\t\t\t\t<div><label for=\"wpsl-search-input\">Votre emplacement<\/label><\/div>\r\n\t\t\t\t<input id=\"wpsl-search-input\" type=\"text\" value=\"\" name=\"wpsl-search-input\" placeholder=\"\" aria-required=\"true\" \/>\r\n\t\t\t<\/div>\r\n\t\t\t<div class=\"wpsl-select-wrap\">\r\n\t\t\t\t<div id=\"wpsl-radius\">\r\n\t\t\t\t\t<label for=\"wpsl-radius-dropdown\">Rayon de recherche<\/label>\r\n\t\t\t\t\t<select id=\"wpsl-radius-dropdown\" class=\"wpsl-dropdown\" name=\"wpsl-radius\">\r\n\t\t\t\t\t\t<option value=\"10\">10 km<\/option><option value=\"25\">25 km<\/option><option selected=\"selected\" value=\"50\">50 km<\/option><option value=\"100\">100 km<\/option><option value=\"200\">200 km<\/option><option value=\"500\">500 km<\/option>\r\n\t\t\t\t\t<\/select>\r\n\t\t\t\t<\/div>\r\n\t\t\t<\/div>\r\n\t\t\t\t<div class=\"wpsl-search-btn-wrap\"><input id=\"wpsl-search-btn\" type=\"submit\" value=\"Recherche\"><\/div>\r\n\t\t<input type=\"hidden\" name=\"trp-form-language\" value=\"fr\"\/><\/form>\r\n\t\t<\/div>\r\n\t<\/div>\r\n\t<div id=\"wpsl-gmap\" class=\"wpsl-gmap-canvas\"><\/div>\r\n\t<div id=\"wpsl-result-list\">\r\n\t\t<div id=\"wpsl-stores\" >\r\n\t\t\t<ul><\/ul>\r\n\t\t<\/div>\r\n\t\t<div id=\"wpsl-direction-details\">\r\n\t\t\t<ul><\/ul>\r\n\t\t<\/div>\r\n\t<\/div>\r\n<\/div>\r\n<\/div><div class=\"bde-button-77-271 bde-button\">\n        \n    \n    \n    \n    \n            \n                    \n            \n            \n\n    \n    \n    \n    \n    \n    <a class=\"breakdance-link button-atom button-atom--custom bde-button__button\" href=\"#qualify\" target=\"_self\" data-type=\"url\"  >\n\n    \n        <span class=\"button-atom__text\">V\u00e9rifiez si vous \u00eates pr\u00e9qualifi\u00e9<\/span>\n\n                            \n        \n                <\/a>\n\n    \n\n\n<\/div><div class=\"bde-button-77-320 bde-button\">\n        \n    \n    \n    \n    \n            \n                    \n            \n            \n\n    \n    \n    \n    \n    \n    <a class=\"breakdance-link button-atom button-atom--custom bde-button__button\" href=\"#qualify-mobile\" target=\"_self\" data-type=\"url\"  >\n\n    \n        <span class=\"button-atom__text\">V\u00e9rifiez si vous \u00eates pr\u00e9qualifi\u00e9<\/span>\n\n                            \n        \n                <\/a>\n\n    \n\n\n<\/div><\/div>\n<\/section>","protected":false},"excerpt":{"rendered":"<p>One Dose:&nbsp;Could it help conquer high cholesterol? You may be able to take part in the Heart-2 study. Studies Home The Heart-2 study will help determine if a single dose of an investigational medicine, called VERVE-102, can safely and permanently reduce low-density lipoprotein cholesterol (LDL-C) or \u201cbad\u201d cholesterol in people with heterozygous familial hypercholesterolemia (HeFH) [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"inline_featured_image":false,"_breakdance_hide_in_design_set":false,"_breakdance_tags":"","footnotes":""},"class_list":["post-77","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/heart2study.com\/fr\/wp-json\/wp\/v2\/pages\/77","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/heart2study.com\/fr\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/heart2study.com\/fr\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/heart2study.com\/fr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/heart2study.com\/fr\/wp-json\/wp\/v2\/comments?post=77"}],"version-history":[{"count":148,"href":"https:\/\/heart2study.com\/fr\/wp-json\/wp\/v2\/pages\/77\/revisions"}],"predecessor-version":[{"id":900,"href":"https:\/\/heart2study.com\/fr\/wp-json\/wp\/v2\/pages\/77\/revisions\/900"}],"wp:attachment":[{"href":"https:\/\/heart2study.com\/fr\/wp-json\/wp\/v2\/media?parent=77"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}